Brand Name: Wellbutrin XL extended-release tablets
Generic Name: bupropion (bue-PROE-pee-on)
Pharmacology: Bupropion is an inhibitor of the neuronal uptake of norepinephrine and dopamine. It does not affect serotonin.
Contraindications: History of seizures, recent head injury, current or past history of eating disorder, and patients current taking a class of antidepressants called MAO Inhibitors.
Dosage Forms: 150 mg, 300 mg tablets. There is a 450 mg tablet sold under the brand name Forfivo.
Dosing: Initial starting dose is 150 mg once daily in the morning without regard to meals. The usual adult target dose is 300 mg once a day (maximum recommended dose is 450 mg per day).
Habit Forming: No
Pregnancy: Risk Category C (animal studies do not show adverse effects, but no controlled studies in humans).