Wellbutrin for ADHD

Non-stimulant medication for Attention-Deficit Hyperactivity Disorder

Brand Name:  Wellbutrin XL extended-release tablets

Generic Name: bupropion (bue-PROE-pee-on)

Pharmacology:  Bupropion is an inhibitor of the neuronal uptake of norepinephrine and dopamine.  It does not affect serotonin.  

Contraindications:  History of seizures, recent head injury, current or past history of eating disorder, and patients current taking a class of antidepressants called MAO Inhibitors.

Dosage Forms:  150 mg, 300 mg tablets.  There is a 450 mg tablet sold under the brand name Forfivo.

Dosing:  Initial starting dose is 150 mg once daily in the morning without regard to meals. The usual adult target dose is 300 mg once a day (maximum recommended dose is 450 mg per day).

Habit Forming:  No

Pregnancy:  Risk Category C (animal studies do not show adverse effects, but no controlled studies in humans).

Wellbutrin Side Effects

Wellbutrin (Bupropion) is generally well tolerated, with a low incidence of sexual side effects and weight gain, but like all medications, it may cause side effects.  The top ten most frequent side effects are:

  • Irritability 29%
  • Dry Mouth 28%
  • Headache 26%
  • Constipation 25%
  • Nausea 22%
  • Dizziness 22%
  • Excessive Sweating 22%
  • Tremor 21%
  • Sedation 20%
  • Insomnia 19%

FDA Package Insert for Wellbutrin (Bupropion)

Wellbutrin formulations