Wellbutrin for ADHD
Brand Name: Wellbutrin XL extended-release tablets
Generic Name: bupropion (bue-PROE-pee-on)
Pharmacology: Bupropion is an inhibitor of the neuronal uptake of norepinephrine and dopamine. It does not affect serotonin.
Contraindications: History of seizures, recent head injury, current or past history of eating disorder, and patients current taking a class of antidepressants called MAO Inhibitors.
Dosage Forms: 150 mg, 300 mg tablets. There is a 450 mg tablet sold under the brand name Forfivo.
Dosing: Initial starting dose is 150 mg once daily in the morning without regard to meals. The usual adult target dose is 300 mg once a day (maximum recommended dose is 450 mg per day).
Habit Forming: No
Pregnancy: Risk Category C (animal studies do not show adverse effects, but no controlled studies in humans).
Wellbutrin Side Effects
Wellbutrin (Bupropion) is generally well tolerated, with a low incidence of sexual side effects and weight gain, but like all medications, it may cause side effects. The top ten most frequent side effects are:
- Irritability 29%
- Dry Mouth 28%
- Headache 26%
- Constipation 25%
- Nausea 22%
- Dizziness 22%
- Excessive Sweating 22%
- Tremor 21%
- Sedation 20%
- Insomnia 19%
Peer-Reviewed Articles on Wellbutrin for ADHD
- Bupropion for Adults with Attention-Deficit Hyperactivity Disorder: Meta-analysis of randomized, placebo-controlled trials.
- Bupropion in Adults with Attention-Deficit/Hyperactivity Disorder: a Randomized, Double-blind Study.
- A systematic review of randomized controlled trials of bupropion versus methylphenidate in the treatment of attention-deficit/hyperactivity disorder
- Bupropion versus Methylphenidate in the Treatment of Attention-Deficit Hyperactivity Disorder
- Bupropion SR vs. methylphenidate vs. placebo for Attention Deficit Hyperactivity Disorder in Adults.
- An Open Trial of Sustained Release Bupropion for Attention-Deficit/Hyperactivity Disorder in Adults with ADHD plus Substance Use Disorders.